The Fredericktown Multiple Resource Area was listed on the National Register of Historic Places on November 6, 1979 by Steven McQuillin. A Multiple Resource Area is a collection of buildings that share a common theme, but are too scattered to constitute a complete district.
The historic resources of Fredericktown consist primarily of mid- to late-19th century buildings. The central business area is largely Italianate in character. A small handful of frame construction Greek Revival commercial structures still exist at the southern end of downtown. Surrounding downtown are older residential buildings in several different architectural styles, including Greek Revival, Queen Anne, Italianate, and Gothic Revival.